Which test includes MSI and TMB metrics for profiling tumors?

Which test includes MSI and TMB metrics for profiling tumors?

• A. Precise Tumor
• B. MyChoice CDx
• C. BRACAnalysis
• D. Oncoplex

Answer: (A)

Tumor profiling that reports both microsatellite instability (MSI) and tumor mutational burden (TMB) helps identify tumors likely to respond to immunotherapy, since MSI-H reflects mismatch repair deficiency and high TMB indicates a higher number of neoantigens. Among common profiling panels, the test that provides both MSI status and a TMB calculation is Oncoplex, making it the best fit for profiling tumors with these two metrics. The other options are more focused on different aspects: BRACAnalysis assesses germline BRCA mutations, MyChoice CDx centers on homologous recombination deficiency related to BRCA pathways, and Precise Tumor isn’t typically recognized for routinely delivering both MSI and TMB.

Tumor profiling that reports both microsatellite instability (MSI) and tumor mutational burden (TMB) helps identify tumors likely to respond to immunotherapy, since MSI-H reflects mismatch repair deficiency and high TMB indicates a higher number of neoantigens. Among common profiling panels, the test that provides both MSI status and a TMB calculation is Oncoplex, making it the best fit for profiling tumors with these two metrics. The other options are more focused on different aspects: BRACAnalysis assesses germline BRCA mutations, MyChoice CDx centers on homologous recombination deficiency related to BRCA pathways, and Precise Tumor isn’t typically recognized for routinely delivering both MSI and TMB.