What does ctDNA stand for?

What does ctDNA stand for?

• A. Circulating tumor DNA
• B. Circulating tumor antigen
• C. Circulating transcription DNA
• D. Circulated tumor DNA

Answer: (A)

Circulating tumor DNA presents the idea that fragments of DNA from tumor cells spill into the bloodstream. These DNA pieces can be detected in a blood sample, enabling a noninvasive “liquid biopsy” to identify tumor-specific mutations, monitor how well treatment is working, and detect minimal residual disease or early recurrence. The other terms aren’t correct: a circulating tumor antigen would be a protein marker, not DNA; circulating transcription DNA isn’t a standard or meaningful label; and circulated tumor DNA is not the accepted terminology.

Circulating tumor DNA presents the idea that fragments of DNA from tumor cells spill into the bloodstream. These DNA pieces can be detected in a blood sample, enabling a noninvasive “liquid biopsy” to identify tumor-specific mutations, monitor how well treatment is working, and detect minimal residual disease or early recurrence. The other terms aren’t correct: a circulating tumor antigen would be a protein marker, not DNA; circulating transcription DNA isn’t a standard or meaningful label; and circulated tumor DNA is not the accepted terminology.